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Symptoms: Symptoms may include pain, phlebitis and inflammation at site of injection. Dizziness, headache, paresthesia may occur, seizures are possible, especially in renally impaired patients. Laboratory test results may include elevation of bilirubin, BUN, creatinine, liver enzymes, positive Coombs' test and eosinophilia, leucopoenia, thrombocytopenia, thrombocytosis and lengthening of prothrombin time.
Treatment: Treatment should be symptomatic and supportive. It is recommended to monitor coagulation status, haematological, hepatic and renal functions until the patient stabilizes. In the event of seizures, immediately discontinue Zepilen and use anticonvulsant therapy as appropriate and clinically justified. Combined haemodialysis and haemoperfusion may be useful, although no data is available on such use. Peritoneal dialysis is ineffective.
