Treatment of biliary tract, bone & joint, GUT, resp tract, skin & soft tissue infections; endocarditis, septicaemia. Prophylaxis for peri-op patients undergoing contaminated or potentially contaminated surgical procedures or in whom post-op infection would be serious.
IM/IVAdult & elderlyMild infection caused by gram +ve cocci 250-500 mg 8 hrly. Moderate to severe infections 500 mg-1 g 6-8 hrly. Severe life-threatening infection eg, endocarditis or septicaemia 1-1.5 g 6 hrly. Acute uncomplicated UTI 1 g 12 hrly. Pneumonia due to pneumococcal infection 500 mg 12 hrly. Prophylactic use in surgery 1 g 30-60 min prior to surgery, followed by 500 mg-1 g 6 hrly post-op for 24 hr. If surgery is >2 hr, administer an additional dose of 500 mg-1 g during the surgical procedure. Patient who have undergone open heart surgery or prosthesis implantationProlong prophylactic administration for 3-5 days post-surgery. ChildnMild to moderate infections Total daily dose: 25-50 mg/kg body wt given as 3 or 4 equally divided doses. Severe infection Total daily dose: Up to 100 mg/kg body wt given as 3 or 4 equally divided doses.
Previous hypersensitivity reactions to penicillins. May cause false +ve Coomb's test. Monitor for pseudomembranous colitis. Drug w/drawal in severe cases. Discontinue use if an allergic reaction occurs. Patients w/ history of GI disease especially colitis. Monitor for signs of superinfection during long-term therapy. Renal impairment. Intrathecal is not an approved route of administration. Pregnancy & lactation. Infants & neonates <1 mth.
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