Zepilen Adverse Reactions

Although generally well tolerated, the following undesirable effects have been reported: Dermatological: There are infrequent reports of pain, on occasion accompanied by indurations, following IM injection. Following IV injection there have been observations of phlebitis at the injection site.
Gastrointestinal System: Pseudomembranous colitis symptoms may occur during or after treatment. Anorexia, diarrhoea, nausea, oral candidiasis and vomiting have been reported.
Genital System: Reports of genital and anal pruritus, genital candidiasis and vaginitis.
Haematological: Positive direct and indirect Coombs' test, leucopoenia, neutropenia, thrombocythaemia, sporadic cases of hypoprothrombinemia reversible by vitamin K have been reported, thrombocytopenia.
Hepatic System: Rare observation of transient rise in ALP, ALT and AST levels. There are rare reports of transient cholestatic jaundice and hepatitis.
Hypersensitivity: Anaphylaxis, drug fever, eosinophilia, rash, Stevens-Johnson syndrome and vulvar pruritus.
Neurological System: Occasional reports of convulsions, often associated with high dose administration in marked renal impairment.
Renal System: Transient rise in blood urea nitrogen, unaccompanied by clinically evident renal impairment. Rare reports of interstitial nephritis and other renal disorders. Most of these reports were from seriously ill patients on multiple drug therapy, definite causality has not been determined.