Zepilen Mechanism of Action

Pharmacology: Pharmacodynamics: Cefazolin is a cephalosporin antibiotic with bactericidal properties. It acts by interference of the final stage of bacterial cell wall synthesis in both gram-positive and gram-negative bacteria.
Pharmacokinetics: The parenteral route of administration is used for cefazolin due to the poor absorption from the gastrointestinal tract. Following IM administration of a 500 mg dose, peak plasma levels ca 30 g/mL, occur in about 1 hr. Plasma protein-binding is about 90%. With normal renal function the half life is about 1.8 hrs. Cefazolin is excreted unchanged in the urine with about 80% the dose being recovered over 24 hrs post administration.
Toxicology: Preclinical Safety Data: Animal studies showed no sign of reduced fertility or teratogenicity. Animal studies have indicated that concurrent use with potent diuretics may lead to an increased risk of renal toxicity.
Microbiology: Cefazolin, in vitro, is active against: Gram Positive Organisms: Staphylococcus aureus (both penicillin sensitive and resistant), Staphylococcus epidermidis, group A β-haemolytic streptococci, and other strains of streptococci (many enterococci strains are resistant), Streptococci pneumoniae.
Gram Negative Organisms: Enterobacter aerogenes, Escherichia coli, Haemophilus influenzae, Klebsiella sp, Proteus mirabilis.