Patients known to be hypersensitive to penicillin should be given an antibiotic of another class. Care is necessary if very high doses of penicillin are given especially if renal function is poor because of the risk of nephrotoxicity. Care is necessary for treating patients with syphilis because Jarisch-Herxheimer's reaction may occur. It should preferably not be given to patients with infectious mononucleosis since they are especially susceptible to Cloxacillin-induced skin rash.
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