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It is also possible that nausea, diarrhoea, digestive disorders, or skin rashes in the form of maculopapular exanthem may be seen.
The incidence of skin rash due to Cloxacillin is similar to that observed in patients suffering from infectious mononucleosis.
These adverse effects include hemolytic anaemia and neutropenia both of which might have some immunological basis, prolongation of bleeding time& defective platelet function.
Convulsion and other signs of central nervous system toxicity followed intrathecal administration.
Some patients with syphilis and other spirochaete infections may experience a Jarisch Herxheimer reaction shortly after starting treatment with penicillin, which probably due to the release of endotoxins from the killed treponemes. Symptoms include fever, chills, headache, and reaction at the site of lesions. The reaction can be dangerous in cardiovascular syphilis or where there is a serious risk of increased local damage such as optic atrophy.
