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Cloxacillin injection is intended for intramuscular, intravenous, intrapleural, and intra-articular use.
The recommended dosages are given as follows. In severe, stubborn infections, a higher dosage may be administered.
Adults: Intramuscular Use: 250 mg every 4-6 hours.
Intravenous Use: 500 mg every 4-6 hours, administered into a vein either directly or via a drip-tube for 3-4 min.
More rapid administration may result in convulsive seizures.
Infants and Children: In infants up to 2 years of age, one-quarter of the adult dosage.
In children 2-10 years of age, half the adult dosage.
Renal Insufficiency: In the presence of severe renal impairment (creatinine clearance <10 ml/min), a reduction in dose or extension of dose interval should be considered.
Preparation of the Solution: Before reconstitution, Cloxacillin vials should be stored in a cool dry place. Solutions for injections should be freshly prepared.
If Cloxacillin is prescribed concurrently with an aminoglycoside, the two antibiotics should not be mixed in the same syringe, intravenous fluid container, or giving set because the loss of activity of the aminoglycoside can occur under these conditions.
Cloxacillin injection should not be mixed with proteinaceous fluids such as protein hydrolysates, blood or plasma, or with intravenous lipid emulsions. (See Table 1.)
Please note: The reconstituted solution must be shaken well before use.
Click on icon to see table/diagram/imageIV Infusion Entire contents of the vial to be dissolved in 5 mL Water for Injections. Further, dilute the solution in 125 to 250 mL of isotonic solutions respectively. Shake well to dissolve.
Administer total contents of the vial by slow infusion over 30-40 minutes.
Immediate use of the reconstituted solution is recommended.
Stability of the Reconstituted Solution: The dosing consideration; the diluents to be used, the storage temperature, and the stability recommended are: (See Table 2.)
Click on icon to see table/diagram/image