Cloxabiotic Drug Interactions

The administration of probenecid with Cloxacillin results in higher serum peak concentrations and prolongs serum concentrations of Cloxacillin.
Concurrent use with allopurinol may increase the possibility of skin rash, especially in hyperuricemic patients.
Antidiarrheals, antiperistaltic (for example, opiates and diphenoxylate and atropine): Penicillins may cause pseudomembranous colitis which may result in severe watery diarrhoea. Concurrent or subsequent administration of antiperistaltic antidiarrheals is not recommended since they may delay the removal of toxins from the colon, thereby prolonging and/or worsening diarrhoea.
Chloramphenicol or erythromycin or sulfonamides or tetracyclines may interfere with the bactericidal effect of penicillins in the treatment of meningitis or other situations where a rapid bactericidal effect is necessary. It is best to avoid concurrent therapy. Chloramphenicol and Cloxacillin are sometimes administered concurrently in paediatric patients.
Concurrent use with contraceptive, oral, may decrease the effectiveness of oral contraceptives Stimulation of estrogen metabolism or reduction in the enterohepatic circulation of estrogen can cause menstrual irregularities, intermenstrual bleeding, and unplanned pregnancies. The patient should be advised to use an alternate method of contraception while taking any of these penicillins. Probenecid may decrease renal tubular secretion of penicillins when used concurrently.