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Do not store above 30°C. Do not freeze.
A solution for bolus injection is prepared by dissolving the drug product Meronem in water for injection to a final concentration of 50 mg/mL. Chemical and physical in-use stability for a prepared solution for bolus injection has been demonstrated for 3 hrs at up to 25°C or 16 hrs under refrigerated conditions (2-8º C).
A solution for infusion is prepared by dissolving the drug product Meronem in either 0.9% sodium chloride solution for infusion or 5% glucose (dextrose) solution for infusion to a final concentration of 1 to 20 mg/mL. Chemical and physical in-use stability for a prepared solution for infusion using 0.9% sodium chloride solution has been demonstrated for 3 hrs at up to 25°C or 15 hrs under refrigerated conditions (2-8°C). Constituted solutions of Meronem in 5% glucose (dextrose) solution should be used immediately.
The constituted solutions should not be frozen.
From a microbiological point of view, unless the method of opening/constitution/dilution precludes the risk of microbiological contamination, the product should be used immediately.
If not used immediately, in-use storage times and conditions are the responsibility of the user.
