Meronem Drug Interactions

Probenecid competes with meropenem for active tubular secretion and thus, inhibits the renal excretion, with the effect of increasing the elimination half-life and plasma concentration of meropenem. As the potency and duration of action of Meronem dosed without probenecid are adequate, the co-administration of probenecid with Meronem is not recommended.
The potential effect of Meronem on the protein-binding of other drugs or metabolism has not been studied. However, the protein-binding of Meronem is low that no interactions with other compounds would be expected on the basis of this mechanism.
Decreases in blood levels of valproic acid have been reported when it is co-administered with carbapenem agents resulting in a 60-100% decrease in valproic acid levels in about 2 days. Due to the rapid onset and the extent of the decrease, co-administration of Meronem in patients stabilised on valproic acid is not considered to be manageable and therefore, should be avoided (see Precautions).
Meronem has been administered concomitantly with other medications without adverse pharmacological interactions. However, no specific drug interactions studies other than probenecid were conducted.
Incompatibilities: Meronem should not be mixed with or physically added to solutions containing other drugs.