Meronem Dosage/Direction for Use

The dosage and duration of therapy should be established depending on type and severity of infection and the condition of the patient.
Adults: Treatment of Pneumonia, Urinary Tract Infections, Gynecological Infections eg, Endometritis, Skin and Skin Structure Infections: Recommended Daily Dosage: 500-mg IV every 8 hrs.
Treatment of Nosocomial Pneumonias, Peritonitis, Presumed Infections in Neutropenic Patients and Septicemia: 1 g IV every 8 hrs.
Meningitis: Recommended Dosage: 2 g every 8 hrs.
When treating infections known or suspected to be caused by Pseudomonas aeruginosa, a dose of at least 1 g every 8 hours in adults (maximum approved dose is 6 g daily given in 3 divided doses) and a dose of at least 20 mg/kg every 8 hours in children (maximum approved dose is 120 mg/kg daily given in 3 divided doses) are recommended. Regular sensitivity testing is recommended when treating Pseudomonas aeruginosa infection.
Adults with Impaired Renal Function: Dosage should be reduced in patients with CrCl <51 mL/min, as scheduled as follows. (See table.)


Click on icon to see table/diagram/image


Meropenem is cleared by hemodialysis and hemofiltration; if continued treatment with Meronem is necessary, the unit dose based on the infection type and severity is recommended at the completion of the hemodialysis procedure to re-institute effective treatment.
There is no experience with peritoneal dialysis.
Adults with Hepatic Insufficiency: No dosage adjustment is necessary in patients with hepatic impairment.
Children >3 months up to 12 years: Recommended Dose: 10-20 mg/kg every 8 hrs depending on type and severity of infection, the known or suspected susceptibility of the pathogens and the condition of the patient.
Children >50 kg body weight: Adult dosage should be used.
Meningitis: Recommended Dose: 40 mg/kg every 8 hrs.
There is no experience in children with renal impairment.
Elderly: No dosage adjustment is required for the elderly with normal renal function or creatinine clearance values >50 mL/min.
Administration: Meronem should be given as an IV bolus injection over approximately 5 min or by IV infusion over approximately 15-30 min. There is limited safety data available to support the administration of a 40 mg/kg bolus dose.