IV bolus inj over approx 5 min or IV infusion over approx 15-30 min. AdultPneumonia, UTI, gynecological infections eg, endometritis, skin & skin structure infections 500 mg IV 8 hrly. Nosocomial pneumonias, peritonitis, presumed infections in neutropenic patients, septicemia 1 g IV 8 hrly. Meningitis 2 g 8 hrly. Childn >3 mth-12 yr 10-20 mg/kg 8 hrly, >50 kg Adult dose. Meningitis 40 mg/kg 8 hrly.
History of hypersensitivity to carbapenems, penicillins or other β-lactams. Overgrowth of nonsusceptible organisms may occur. Use in infections caused by methicillin resistant staphylococci. Monitor levels of transaminase & bilirubin in patients w/ hepatic disease. History of GI complaints, particularly colitis. Monitor liver function. A +ve direct or indirect Coombs test may develop. May impair ability to drive or operate machinery. Pregnancy & lactation. Infant <3 mth.
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