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Pharmacology: Pharmacodynamics: Moxilen is a broad spectrum antibiotic. It is rapidly bactericidal and possesses the safety profile of a penicillin. The wide range of organisms sensitive to the bactericidal action of Moxilen include: Aerobes: Gram-positive include: Streptococcus faecalis, Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus viridans, Staphylococcus aureus, (Penicillin-sensitive strains only): Corynebacterium species, Bacillus anthracis, Listeria monocytogenes.
Gram-negative include: Haemophilus influenza, Escherichia coli, Proteus mirabilis, Salmonella species, Shigella species, Bordetella pertussis, Brucella species, Neisseria gonorrhoeae, Neisseria meningitidis, Vibrio cholerae, Pasteurella septica.
Anaerobes: Gram-positive: Clostridium species.
Pharmacokinetics: Amoxicillin is well absorbed by both parenteral and oral routes. Oral administration, usually at convenient three times daily dosage, produces high serum levels independent of the time at which food is taken. Moxilen gives good penetration into bronchial secretions and high urinary concentrations of unchanged antibiotics.
Toxicology: Preclinical Safety Data: No further information of relevance to the prescriber that is not addressed elsewhere in the monograph.
