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Allopurinol: concurrent administration may increase the incidence of rash and other allergic skin reactions.
Anticoagulants: there are rare reports of prolongation of prothrombin time in patients concomitantly on amoxicillin. It is recommended that appropriate monitoring is carried out when amoxicillin is prescribed concurrently with anticoagulants.
Oral contraceptives: In common with other antibiotics, amoxicillin may affect the gut flora, leading to lower oestrogen reabsorption and reduced efficacy of combined oral contraceptives.
Probenecid: decreases the renal tubular secretion of amoxicillin. Concurrent use with amoxicillin may result in increased and prolonged blood levels of amoxicillin.
Laboratory Tests: Glucose in Urine: Due to the high urinary concentrations of amoxicillin, false positive readings are common with chemical methods.
The use of enzymatic glucose oxidase methods is recommended, as there is no interference from amoxicillin.
