Moxilen Dosage/Direction for Use

Adults (including the elderly patients): Standard adult dosage: 250 mg 3 times daily, increasing to 500 mg 3 times daily for more severe infections.
High dosage therapy (maximum recommended oral dosage is 6 g daily in divided doses): A dosage of 3 g twice daily is recommended in appropriate cases for the treatment of severe or recurrent purulent infection of the respiratory tract.
Short course therapy: Simple acute urinary tract infection: two 3 g doses with 10 to12 hours between the doses.
Dental abscess: two 3 g doses with 8 hours between the doses.
Gonorrhoea: single 3 g dose.
Helicobacter eradication in peptic (duodenal and gastric) ulcer disease: ''Moxilen'' is recommended at a dose of twice daily in association with a proton pump inhibitor and antimicrobial agents detailed as follows: Omeprazole 40 mg daily, amoxicillin 1 g twice a day, clarithromycin 500 mg twice a day for 7 days; or Omeprazole 40 mg daily, amoxicillin 750 mg to 1 g twice a day, Metronidazole 400 mg 3 times a day for 7 days.
Children's dosage (up to 10 years of age): Standard children first dosage: 125 mg 3 times daily, increasing to 250 mg 3 times daily for more severe infections.
''Moxilen" powder for oral suspension is recommended for children under 6 months of age.
In severe or recurrent acute otitis media, especially where compliance may be a problem, 750 mg twice a day for 2 days may be used as an alternative course of treatment in children aged 3 to 10 years.
The use of Moxilen 750 mg Sachets Syrup Forte is recommended.
Patients with renal impairment: In renal impairment, the excretion of the antibiotic will be delayed and, depending on the degree of impairment, it may be necessary to reduce the total daily dosage according to the following scheme: Adults and children over 40 kg: Mild Impairment (creatinine clearance greater than 30 ml/min): No change in dosage.
Moderate Impairment (creatinine clearance 10 to 30 mL/min): 500 mg twice a day maximum.
Severe Impairment (creatinine clearance less than 10 mL/min): 500 mg/day maximum.
Children under 40 kg: Mild Impairment (creatinine clearance greater than 30 mL/min): No change in dosage.
Moderate Impairment (creatinine clearance 10 to 30 mL/min): 15 mg/kg twice a day (maximum 500 mg twice daily).
Severe Impairment (creatinine clearance less than 10 mL/min):15 mg/kg once a day (maximum 500 mg).
Patients receiving peritoneal dialysis: Dosing as for patients with severe renal impairment (creatinine clearance less than 10 ml/min). Amoxicillin is not removed by peritoneal dialysis
Patients receiving haemodialysis: Dosing as for patients with severe renal impairment (creatinine clearance less than 10 ml/min). Amoxicillin is removed from the circulation by haemodialysis. Therefore, 1 additional dose (500 mg for adults or 15 m g/kg for children under 40 kg) may be administered during dialysis and at the end of each dialysis.
Prophylaxis of endocarditis: See table as follows.

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Parenteral therapy is indicated if the oral route is considered impracticable or unsuitable, and particularly for the urgent treatment of severe infection.
In renal impairment the excretion of the antibiotic will be delayed and depending on the degree of impairment, it may be necessary to reduce the total daily dosage.