Accidental ingestion of large doses rarely occurs, however prolonged use and abuse of the drug causes cushingoid changes, moon face, striae, central obesity, hirsutism, acne, ecchymoses, hypertension, osteoporosis, myopathy, sexual dysfunction, diabetes mellitus, hyperlipidemia, peptic ulcer, GI bleeding, increased susceptibility to infection, electrolyte and fluid imbalance and psychosis. Acute treatment of overdoses nesessitates immediate gastric lavage or emesis followed by supportive and symptomatic treatment.
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