Xilone Mechanism of Action

Properties: Prednisolone is an adrenocorticoid with both glucocorticoid and mineralocorticoid properties. Its glucocorticoid potency is four times the potency of equal weight of hydrocortisone. Its mineralocorticoid properties are rather weak and are only one half the potency of hydrocortisone.
Action: Prednisolone acts as follows: Controls the rate of protein synthesis.
Depresses the migration of polymorphonuclear leukocytes and fibroblasts.
Reverses capillary permeability.
Causes lysosomal stabilization at the cellular level to prevent or control inflammation.
Pharmacokinetics: Following oral administration of XILONE Syrup, prednisolone is rapidly and well absorbed from the GIT. Peak plasma concentrations are achieved within 1 - 2 hours. About 50% of prednisolone is bound to plasma proteins. Prednisolone is widely distributed into most body fluids and tissues including muscles, liver, skin, intestine and kidney. Prednisolone is extensively metabolized in the liver into sulfate and glucuronide conjugates which are eliminated in urine. Small amounts of prednisolone are eliminated unchanged in urine. Plasma elimination half-life is 2 - 4 hours. Prednisolone crosses the placenta and appears in breast milk.