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Hepatic microsomal enzyme inducers including barbiturates, phenytoin, ephedrine, carbamezepine and rifampin may decrease the corticosteroids effects.
Aspirin, indomethacin and other NSAIDs may increase the risk of GI distress, bleeding and ulcers.
Thiazides and diuretics may increase the risk of hypokalemia due to potassium wasting effect of prednisolone.
The effects of hypoglycemic agents (including insulin) and antihypertensives are antagonized by corticosteroids.
There is a potential for an increased risk of digitalis toxicity associated with hypokalemia when corticosteroids and cardiac glycosides are used concomitantly.
Corticosteroids may alter the response to coumarin.
