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Category C: NSAIDs inhibit prostaglandin synthesis and, when given during the latter part of pregnancy, may cause closure of the foetal ductus arteriosus, foetal renal impairment, inhibition of platelet aggregation and delay labour and birth. Continuous treatment with NSAIDs during the last trimester of pregnancy should only be given on sound indications. During the last few days before expected birth, agents with an inhibitory effect on prostaglandin synthesis should be avoided. Children under 12 years are not likely to become pregnant.
Ibuprofen appears in breast milk in very low concentrations and is not recommended for lactating women. Children under 12 years are not likely to breastfeed.
