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Pharmacology: Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) of propionic acid derivative. It exhibits analgesic, anti-inflammatory and antipyretic activities and is effective in the relief of inflammation, pain and fever. It is thought that the anti-inflammatory effect of Ibuprofen is produced to a degree by inhibiting the production of prostaglandins. Analgesic and antipyretic activity have been shown with Ibuprofen in animal and human studies, providing symptomatic relief of pain and inflammation in conditions such as musculoskeletal and joint disorders, rheumatoid arthritis and allied conditions.
Following oral administration of Ibuprofen suspension in febrile children, plasma concentration-time curves (AUCs) increase with increasing single Ibuprofen doses up to 10 mg/kg. It appears that the pharmacokinetics of Ibuprofen is not affected by age, in children 2 to 11 years of age. In children, the antipyretic effect of Ibuprofen suspension begins 1 hour after oral administration and peaks within 2 to 4 hours. The antipyretic effect of single Ibuprofen suspension doses of 5 or 10 mg/kg may last up to 6 or 8 hours respectively.
