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Symptoms: Ibuprofen is less toxic in acute overdose if compared to either Aspirin or Paracetamol. Depression of the central nervous system and the respiratory system may occur as a result of overdosage. Nausea, vomiting, stomach pain, tinnitus, headache, confusion, drowsiness, coma and unsteadiness may also occur.
Treatments: There is no specific antidote for overdose with Ibuprofen. Gastric lavage or induced vomiting in the conscious patient may be performed if not more than an hour has elapsed since ingestion. As Ibuprofen is acidic and is excreted in the urine, alkalinisation of the urine may promote more rapid excretion. In addition to supportive measures, the use of oral activated charcoal may help to reduce the absorption of Ibuprofen.
