Sign Out
Care should be taken in patients treated with any of the following drugs as interactions have been reported in some patients: Antihypertensives: Reduced antihypertensive effect.
Diuretics: Reduced diuretic effect. Diuretics can increase the risk of nephrotoxicity of NSAIDs.
Cardiac glycosides: NSAIDs may exacerbate cardiac failure, reduce GFR and increase plasma cardiac glycoside levels.
Lithium: Decreased elimination of lithium.
Methotrexate: Decreased elimination of methotrexate.
Cyclosporin: Increased risk of nephrotoxicity with NSAIDs.
Mifepristone: NSAIDs should not be used for 8 - 12 days after mifepristone administration as NSAIDs can reduce the effects of mifepristone.
Other analgesics: Avoid concomitant use of two or more NSAIDs.
Corticosteroids: Increased risk of gastrointestinal bleeding.
Anticoagulants: Enhanced anticoagulant effect.
Quinolone antibiotics: Patients taking NSAIDs and quinolones may have an increased risk of developing convulsions.
