Related to the presence of carbocisteine: Risk of severe bronchial congestion particularly in infants and in some patients incapable of effective expectoration.
Allergic skin reactions such as pruritus, erythematous eruption, urticaria and angioedema.
A few cases of fixed drug eruption have been reported.
Possibility of gastrointestinal intolerance symptoms (gastric pain, nausea, diarrhea). In this event it is recommended to reduce the dosage.
Related to the presence of promethazine: The pharmacological characteristics of the substance are responsible for more or less severe adverse effects, which may or may not be related to the dose.
Autonomic nervous system effect: Sedation or drowsiness, more marked at the beginning of treatment; Anticholinergic effects, such as dryness of the mucosae, constipation, accommodation disorders, mydriasis, cardiac palpitations, risk of urine retention; Postural hypotension; Balance disorders, dizziness, impaired memory or concentration; Lack of motor coordination, tremor (more frequent in the elderly); Confusion, hallucinations; More rarely, excitatory effects agitation, nervousness, insomnia.
Sensitization reactions: Erythema, eczema, pruritis, purpura, urticaria, possibly giant urticaria; asthma attack; edema, more rarely angioedema; Anaphylactic shock; Photosensitization.
Hematological effects: Leucopenia, neutropenia, exceptional cases of agranulocytosis; Thrombocytopenia; Hemolytic anemia.