Patients on ofloxacin should be cautioned to avoid excessive exposure to direct sunlight while receiving the drug. If photosensitivity occurs (eg, skin eruption), ofloxacin should be discontinued.
As with other antibiotics, use of ofloxacin may result in overgrowth of nonsusceptible organisms, especially enterococci or Candida. Resistant strains of some organisms (eg, Pseudomonas aeruginosa, staphylococci) have developed during ofloxacin therapy. Careful monitoring of the patient and periodic in vitro susceptibility tests are essential. If superinfection occurs, appropriate therapy should be instituted.
Ofloxacin should be used with caution in patients with renal or hepatic impairment because elimination of the drug is reduced in these patients.
Effects on the Ability to Drive or Operate Machinery: Adverse effects may affect performance of skilled tasks (eg, driving or handing machinery).
Use in the elderly: Dosage of ofloxacin does not need to be modified in geriatric patients with creatinine clearances >50 mL/min.