Ofloxacin is generally well tolerated, and adverse effects of the drug are similar to those reported with other quinolone antibiotics. The most frequent adverse effects involve the GI tract or the CNS, including nausea, diarrhea, vomiting, abdominal pain/discomfort, abdominal cramps, flatulence, constipation, dyspepsia, heartburn, decreased appetite, dry mouth, headache, insomnia, dizziness, nervousness and sleep disorders. Also reported are rash and pruritus, tachycardia, transient hypotension, hepatitis, cholestatic jaundice, interstitial nephritis, eosinophilia, leukocytosis, anemia.