Clinically important drug interactions of ofloxacin include those with antacids, sucralfate, oral antidiabetics, warfarin and theophylline. Both antacids and sucralfate decrease absorption of oral ofloxacin; effects of oral antidiabetics may be enhanced by ofloxacin; effects of warfarin on prothrombin time and theophylline level may be increased by ofloxacin. With high doses of quinolones, impairment of excretion and an increase in serum levels may occur when co-administered with other drugs that undergo renal tubular secretion, eg probenecid. Other drug interactions include those with aminoglycosides, β-lactam antibiotics and antimycobacterial agents.
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Sign Out
