Naropin

Naropin

ropivacaine

Manufacturer:

Aspen

Distributor:

Zuellig Pharma
Concise Prescribing Info
Contents
Ropivacaine HCl
Indications/Uses
7.5 mg/mL: Surgical anaesth: Epidural block for surgery including caesarean section, major nerve & field block. Acute pain management: Continuous epidural infusion or intermittent bolus administration eg, post-op or labour pain, field block. 2 mg/mL: Acute peri- & post-op pain relief in childn, caudal epidural block & continuous epidural infusion in infants (>30 days) & childn ≤12 yr.
Dosage/Direction for Use
Adult & childn >12 yr 7.5 mg/mL Surgical anaesth: Lumbar epidural in surgery 15-25 mL. Lumbar epidural in caesarean section 15-20 mL. Thoracic epidural for post-op pain relief 5-15 mL. Major nerve block 30-40 mL. Field & minor nerve blocks, infiltration 1-30 mL. 2 mg/mL Lumbar epidural bolus 10-20 mL. Lumbar epidural intermittent inj (top up) eg, labour pain management 10-15 mL (min intervals: 30 min). Continuous infusion eg, labour pain 6-10 mL/hr. Post-op pain management & thoracic epidural for post-op pain relief 6-14 mL/hr. Field blocks 1-100 mL. Childn >30 days-12 yr, up to 25 kg 2 mg/mL Single caudal epidural blocks <T12 1 mL/kg. Childn 1-12 yr, up to 25 kg Continuous epidural infusion Bolus dose: 1 mL/kg. Infusion up to 72 hr: 0.2 mL/kg/hr, 6-12 mth, up to 25 kg Bolus dose: 0.5-1 mL/kg. Infusion up to 72 hr: 0.2 mL/kg/hr, >30 days-6 mth, up to 25 kg Bolus dose: 0.5-1 mL/kg. Infusion up to 72 hr: 0.1 mL/kg/hr.
Contraindications
Hypersensitivity to ropivacaine HCl or other amide-type local anaesth.
Special Precautions
Cross-hypersensitivity w/ other amide–type local anaesth. Not to be used as IA continuous infusion. Avoid intravascular inj, rapid inj site absorption; inj in inflamed areas. Concomitant heart disease; head, neck & major peripheral nerve blocks; hypovolaemia; poor general condition due to age or other compromising factors eg, partial or complete heart conduction block; acute porphyria; chondrolysis. Patients on controlled Na diet. Epidural & spinal anaesth can lead to hypotension & bradycardia; reduce risk of such effects by eg, vasopressor inj. Avoid prolonged use w/ strong CYP1A2 inhibitors. Concomitant use w/ class III antiarrhythmics. May affect ability to drive & use machines. Severe hepatic or renal impairment. Pregnancy & lactation. Neonates. Elderly.
Adverse Reactions
Hypotension; nausea. Bradycardia, tachycardia, HTN; paraesthesia, dizziness, headache; vomiting; urinary retention; temp elevation, rigor, back pain.
Drug Interactions
Additive systemic toxic effects w/ other amide-type local anaesth or structurally-related agents ie, certain antiarrhythmics eg, lidocaine, mexiletine. Increased plasma conc w/ strong CYP1A2 inhibitors eg, fluvoxamine, enoxacin. Class III anti-arrhythmics eg, amiodarone.
MIMS Class
Anaesthetics - Local & General
ATC Classification
N01BB09 - ropivacaine ; Belongs to the class of amides. Used as local anesthetics.
Presentation/Packing
Form
Naropin soln for inj 2 mg/mL
Packing/Price
(Polyamp) 20 mL x 5 × 1's
Form
Naropin soln for inj 7.5 mg/mL
Packing/Price
(Polyamp) 20 mL x 5 × 1's
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