Clavicin Special Precautions

Changes in liver function tests have been observed in some patients receiving Amoxicillin and Clavulanic acid. The clinical significance of these changes is uncertain but Amoxicillin and Clavulanic acid should be used with caution in patients with evidence of severe hepatic dysfunction. Cholestatic jaundice, which may be severe, but is usually reversible, has been reported rarely. Signs and symptoms may not become apparent for several weeks after treatment has ceased. Dosage should be adjusted in patients with renal impairment.
The sodium content must be taken into account in patients on a sodium restricted diet if the parenteral administration of high doses is necessary.
Crystalluria has been observed very rarely in patients with reduced urine output, predominantly with parenteral therapy. During administration of high doses of amoxicillin it is advisable to maintain adequate fluid intake and urinary output in order to reduce the possibility of amoxicillin crystalluria. Amoxicillin has been reported to precipitate in bladder catheters after intravenous administration of large doses. A regular check of potency should be maintained.
Erythematous rashes have been associated with glandular fever in patients receiving amoxicillin.
Prolonged use may occasionally result in overgrowth of non-susceptible organisms.
Effects on ability to drive and use machines: None known.
Use in Elderly: No special precautions have to be taken when prescribing for elderly.