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Prolongation of bleeding time and prothrombin time have been reported in some patients receiving Amoxicillin and Clavulanic acid. It should be used with care in patients on anticoagulation therapy. In common with other broad-spectrum antibiotics, Amoxicillin and Clavulanic acid may reduce the efficacy of oral contraceptives and patients should be warned accordingly. Concomitant use of probenecid is not recommended. Probenecid decreases the renal tubular secretion of amoxicillin. Concomitant use with Amoxicillin and Clavulanic acid may result in increased and prolonged blood levels of amoxicillin but not of clavulanic acid.
Concomitant use of allopurinol during treatment with amoxicillin can increase the likelihood of allergic skin reactions. There are no data on the concomitant use of Amoxicillin and Clavulanic acid and allopurinol.
