Clavicin Adverse Reactions

Side effects are uncommon and mainly of a mild and transitory nature.
Gastrointestinal reactions: Side effects include diarrhoea, indigestion, nausea, vomiting, and mucocutaneous candidiasis have been reported. Antibiotic associated colitis (including pseudomembranous colitis and haemorrhagic colitis) has been reported rarely. Nausea, although uncommon, is more often associated with higher oral dosages.
Renal and urinary tract disorders: Crystalluria has been reported very rarely.
Genito-urinary effects: Vaginal itching, soreness and discharge may occur.
Hepatic effects: Moderate and asymptomatic rises in AST and/or ALT and alkaline phosphatase have been reported occasionally. Hepatitis and cholestatic jaundice have been reported rarely. It has been reported more commonly in the elderly, in males, or in patients with duration of treatment longer than 14 days. Signs and symptoms usually occur during or shortly after treatment but in some cases may not occur until several weeks after treatment has ended. Hepatic reactions are usually reversible but they may be severe and, very rarely, deaths have been reported.
Hypersensitivity reactions: Urticarial and erythematous skin rashes sometimes occur. Rarely erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, bullous exfoliative dermatitis, acute generalised exanthematous pustulosis (AGEP), serum sickness-like syndrome and hypersensitivity vasculitis have been reported. Whenever such disorders occur, treatment should be discontinued. In common with other β-lactam antibiotics angioedema and anaphylaxis have been reported. Intestinal nephritis can occur rarely.
Hematological effects: As with other β-lactams transient leucopenia (including neutropenia and agranulocytosis), thrombocytopenia and haemolytic anaemia have been reported rarely. Prolongation of bleeding time and prothrombin time has also been reported rarely.
CNS effects: CNS effects have been very rarely. These include reversible hyperactivity, dizziness, headache and convulsions. Convulsions may occur with impaired renal function or in those receiving high doses.
Local: Thrombophlebitis at the site of injection has been reported occasionally.