Clamentin Special Precautions

Changes in liver function tests have been observed in some patients receiving Clamentin. The clinical significance of these changes is uncertain but Clamentin should be used with caution in patients with evidence of hepatic dysfunction.
Cholestatic jaundice, which may be severe, but is usually reversible, has been reported rarely. Signs and symptoms may not become apparent for several weeks after treatment has ceased.
In patients with renal impairment, dosage should be adjusted according to the degree of impairment.
Serious and occasionally fatal hypersensitivity (anaphylactoid) reactions have been reported in patients on penicillin therapy. These reactions are more likely to occur in individuals with a history of penicillin hypersensitivity. Prolonged use may also occasionally result in overgrowth of non-susceptible organisms.
In patients with reduced urine output, crystalluria has been observed very rarely, predominantly with parenteral therapy. During the administration of high doses of amoxicillin, it is advisable to maintain adequate fluid intake and urinary output in order to reduce the possibility of amoxicillin crystalluria.
Erythematous rashes have been associated with glandular fever in patients following the use of Amoxicillin. Clamentin should be avoided if glandular fever is suspected.