Tab Adult, childn >12 yr & mild renal impairment (CrCl >30 mL/min) Mild to moderate infections 625 mg bd or 375 mg tds.
Severe infections 1,000 mg bd.
Dental infections 625 mg bd for 5 days.
CrCl <10 mL/min Not >625 mg every 24 hr.
Powd for oral susp Childn 7-12 yr 10 mL tds,
2-7 yr 5 mL tds,
9 mth to 2 yr 25 mg/kg daily in 3 divided doses.
Powd for inj Adult & mild renal impairment (CrCl >30 mL/min) 1.2 g every 8 hr by IV inj or infusion, may be increased to every 6 hr in more serious infections.
Childn 3 mth-12 yr 30 mg/kg every 8 hr, may be increased to every 6 hr in more serious infections,
0-3 mth 30 mg/kg every 12 hr, may be increased to every 8 hr thereafter.
Surgical prophylaxis 1.2 g at induction, may be given further 2-3 doses every 8 hr in 24-hr period for high-risk procedures.
Moderate renal impairment (CrCl 10-30 mL/min) 1.2 g IV stat, followed by 600 mg IV every 12 hr,
severe renal impairment (CrCl <10 mL/min) 1.2 g IV stat, followed by 600 mg IV every 24 hr; additional 600 mg IV may need to be given during & at the end of dialysis.
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