Clamentin Dosage/Direction for Use

Tab: Adults and children over 12 years: Mild to Moderate Infections: 625 mg twice daily.
Severe Infections: One Clamentin Film Coated Tablet 1,000 mg twice daily.
Therapy can be started parentally and continued with an oral preparation.
Dental Infections: 625 mg twice daily for 5 days.
Dosage in Renal Impairment: The Clamentin Film Coated Tablet 1,000 mg should only be used in patients with a glomerular filtration rate of >30 ml/min (see Table 2).

Click on icon to see table/diagram/image

Dosage in Hepatic Impairment: Dose with caution; monitor hepatic function at regular intervals.
Administration: Tablets should be swallowed whole without chewing. If required, tablets may be broken in half and swallowed without chewing.
To minimise potential gastrointestinal intolerance, administer at the start of a meal. The absorption of Clamentin is optimized when taken at the start of a meal.
Treatment should not be extended beyond 14 days without review.
Powd for Oral Susp: Children 7-12 years: 10 mL 3 times daily, 2-7 years: 5 mL 3 times daily, 9 months to 2 years: 25 mg/kg/day in 3 divided doses. Severe infections: Increase frequency to 6 hourly intervals.
Powd for Inj: Adults: By intravenous injection over 3-4 minutes or by intravenous infusion, 1.2 g every 8 hours. Increased to 1.2 g every 6 hours in more serious infections.
Children 3 months-12 years: 30 mg/kg every 8 hours, increased to 30 mg/kg every 6 hours in more serious infections.
Children 0-3 months: 30 mg/kg every 12 hours during the perinatal period and in premature infants, increasing to every 8 hours thereafter.
Surgical Prophylaxis: 1.2 g at induction; for high risk procedures (e.g. colorectal surgery) a further 2-3 doses may be given every 8 hours in a 24-hour period. Continue for several days if the procedure has a significantly increased risk of infection.
Renal Impairment: Adults: Mild impairment (creatinine clearance >30 mL/min) - no change in dosage.
Moderate impairment (creatinine clearance 10-30 mL/min) - 1.2g IV stat, followed by 600 mg IV 12 hourly.
Severe impairment (creatinine clearance <10 mL/min) - 1.2g IV stat, followed by 600 mg IV 24 hourly. An additional 600 mg IV dose may need to be given during dialysis and at the end of dialysis.
Children: Similar reductions in dosage should be made.
Preparation for injection: Clamentin intravenous may be administered either by intravenous injection or by intermittent infusion. It is not suitable for intramuscular administration.
1.2 g vial: To reconstitute dissolve contents in 20 ml of Water For Injection BP.
Intravenous injection: Administer slowly, over a period of 3-4 minutes. Clamentin may be injected directly into a vein or via a drip tube. Intravenous Injections of Clamentin must be administered within 10 minutes.
Intravenous infusion: Add 1.2 g reconstituted solution to 100 ml infusion fluid. The infusion should be given over 30-40 minutes. Solution should be made up to full infusion volume immediately after reconstitution.
Any residual antibiotic solutions should be discarded.