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Minocycline HCl is a semisynthetic tetracycline used in the treatment of a wide variety of infections due to tetracycline-susceptible bacteria and some tetracycline-resistant organisms, eg staphylococci, streptococci and certain strains of E. coli and Haemophilus sp.
Pharmacology: Minocycline HCl acts similarly as the other tetracyclines. It exerts its bacteriostatic effect by inhibiting bacterial protein synthesis. It appears to be generally 2-4 times more potent than tetracycline against gram-positive and gram-negative bacteria, 8 times more potent against S. viridans, but shares equally low potency against S. faecalis. It is especially effective against Mycobacterium marinum.
