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Cases of overdose (2 to 3 times the prescribed dose for several weeks) have been reported with deferasirox. In one case, this resulted in subclinical hepatitis which resolved without long-term consequences after a dose interruption. Single doses of deferasirox up to 80 mg/kg per day with the tablet for oral suspension formulation in iron overloaded β-thalassemic patients have been tolerated with nausea and diarrhea noted. In healthy volunteers, single doses of up to 40 mg/kg per day with the tablet for oral suspension formulation were tolerated.
Acute signs of overdose may include nausea, vomiting, headache, and diarrhea. Overdose should be treated by induction of emesis or by gastric gavage, and by symptomatic treatment.
For management of a suspected drug overdose, contact the regional Poison Control Centre.
