Lopress Special Precautions

A very small percentage of patients may respond in an abrupt and exaggerated manner to the initial dose of Prazosin. Postural hypotension evidenced by dizziness and weakness, or rarely loss of consciousness, has been reported, particularly with the commencement of therapy, but this effect is readily avoided by initiating treatment with a low dose of Prazosin and with small increases in dosage during the first one to two weeks of therapy.
For patients taking medications that are known to lower blood pressure, Prazosin may augment the efficacy of antihypertensive therapy.
Patients with moderate to severe grades of renal impairment, it is recommended that therapy be initiated at 0.5 mg daily and that dosage increases be instituted cautiously.
In patients with benign prostatic hyperplasia: Prazosin is not recommended for patients with a history of micturition syncope.
Effects on ability to drive and use machine: Patients who engage in potentially hazardous activities such as operating machinery or driving motor vehicles should be warned about possible drowsiness, dizziness, or lightheadedness.