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Diuretics and Hypotensive Agents: When Prazosin is administrated with diuretics or other hypotensive agents, particularly β-adrenergic blocking agents (e.g., propranolol), the hypotensive effect of Prazosin may be increased. This effect is usually used to therapeutic advantage, but careful adjustment of dosage is necessary when these drugs are used concomitantly.
Phosphodiesterase Type 5 Inhibitors: Concomitant administration of Prazosin and a phosphodiesterase type 5 (PDE5) inhibitor (e.g. sildenafil, tadalafil, vardenafil) may result in additive hypotensive effects and symptomatic hypotension. Therefore, PDE5 inhibitor therapy should be initiated at lowest possible dosage in patients receiving Prazosin.
Protein-bound drug: Since Prazosin is highly bound to plasma proteins, the possibility that it may interact with other highly protein-bound drugs should be considered.
