Lopress Dosage/Direction for Use

Recommended dose: Hypertension: The recommended starting dose is 0.5 mg taken two or three times daily for 3 to 7 days. If tolerated the dose may then be increased to 1 mg taken two or three times daily for a further 3 to 7 days, and thereafter gradually increased according to patient's response to a usual maximum dose of 20 mg daily in divided dose.
Concomitant therapy with diuretics or other antihypertensives: When diuretics or other hypotensive agents are added to existing Prazosin therapy, the dosage of Prazosin in adults should be reduced to 1 or 2 mg given 3 times daily and gradually increased according to the response and tolerance of the patient. When patients receive other antihypertensive therapy but inadequate control, the dosage of the other drug should be reduced to a maintenance level and Prazosin initiated at 0.5 mg in the evening, then continuing with 0.5 mg twice or three times daily.
Benign Prostatic Hyperplasia: The recommended starting dose is 0.5 mg twice daily, increasing to a maintenance dose not exceeding 2 mg twice daily.
Patients with moderate to severe renal impairment: It is recommended that therapy be initiated at 0.5 mg daily and that dosage increases be instituted cautiously.
Patients with hepatic impairment: It is recommended that therapy be initiated at 0.5 mg daily and that dosage increases be instituted cautiously.
Elderly: Since the elderly may be more susceptible to hypotension, therapy should be initiated with the lowest possible dose.
Pediatric precaution: It is not recommended for the treatment of children under the age of 12 years since safe conditions for its use have not been established.
Mode of Administration: Prazosin hydrochloride is administered orally.
Dosage of Prazosin must be adjusted according to the patient's blood pressure response and tolerance.