Discontinue if GI bleeding or ulceration occurs; at 1st appearance of skin rash, mucosal lesions or any other sign of hypersensitivity; in case of increased SGOT & SGPT. History of allergic conditions; ulcer; oesophagitis, gastritis &/or peptic ulcer; GI disease or toxicity; HTN &/or mild to moderate heart failure; cardiac disease. Glomerular & interstitial nephritis, renal papillary necrosis, nephrotic syndrome & acute renal failure. Patients receiving diuretics or those who develop hypovolaemia; w/ uncontrolled HTN, CHF, established ischaemic heart disease, peripheral arterial &/or cerebrovascular disease; risk factors for CV disease (eg, HTN, hyperlipidaemia, DM, smoking); congenital porphyrin metabolism disorder, dehydration, directly after major surgery; asthma combined w/ chronic rhinitis & sinusitis, &/or nasal polyposis. Patients suffering from haematopoietic disorders, SLE or mixed connective tissue disease. Monitor for digestive disturbances, especially GI bleeding in patients w/ GI symptoms or history of GI disease. Consider therapy w/ protective agents eg, misoprostol or PPIs in patients w/ GI disease or those requiring low dose of ASA or other drugs increasing GI risk. Ensure adequate fluid intake. Regularly check hepatic & renal function, & blood count. Avoid in concomitant use w/ other NSAIDs including COX-2 selective inhibitors. Not recommended w/ other therapy interfering haemostasis eg, warfarin or other coumarins or heparins. Concomitant use w/ oral corticosteroids, anticoagulants eg, warfarin, SSRIs or anti-platelet agents eg, ASA. May affect ability to drive & use machines. Renal & hepatic impairment. May expose fetus to cardiopulmonary toxicity & renal impairment. May impair female fertility & not recommended in women attempting to conceive. Contraindicated during pregnancy (3rd trimester) & lactation. Childn & adolescents. Elderly.