Ketesse tablets must not be administered in the following cases: patients hypersensitive to the active substance, to any other NSAIDs, or to any of the excipients of the product; patients in whom substances with a similar action (e.g. acetylsalicylic acid, or other NSAIDs) precipitate attacks of asthma, bronchospasm, acute rhinitis, or cause nasal polyps, urticaria or angioneurotic oedema; known photoallergic or phototoxic reactions during treatment with ketoprofen or fibrates; patients with history of gastrointestinal bleeding or perforation, related to previous NSAIDs therapy; patients with active peptic ulcer/gastrointestinal haemorrhage or any history of gastrointestinal bleeding, ulceration or perforation; patients with chronic dyspepsia; patients who have other active bleedings or bleeding disorders; patients with Crohn's disease or ulcerative colitis; patients with severe heart failure; patients with moderate to severe renal impairment (creatinine clearance ≤59 ml/min); patients with severely impaired hepatic function (Child-Pugh score 10-15); patients with haemorrhagic diathesis and other coagulation disorders; patients with severe dehydration (caused by vomiting, diarrhoea or insufficient fluid intake); during the third trimester of pregnancy and lactation period (see Use in Pregnancy & Lactation).
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