Edema Usual dose: 25-200 mg daily. Initially 100 mg once daily or in divided doses for at least 5 days.
Essential HTN Initially 50-100 mg once daily or in divided doses continued for at least 2 wk.
CHF Initially 12.5-25 mg daily, may be increased to 50 mg daily after 8 wk of therapy in patients w/ signs & symptoms of progressive heart failure & who had no hyperkalemia (serum K conc 5.5 mEq/L). Decreased to 25 mg every other day if hyperkalemia occurs.
Primary hyperaldosteronism Usual dose: 100-400 mg daily in prep for surgery. Long term: 400 mg daily for 3-4 wk; short term: 400 mg daily for 4 days.
Hypokalemia Usual dose: 25-100 mg daily.
Severe heart failure (NYHA class III-IV) Initially 25 mg once daily in patient w/ serum K ≤5 mEq/L & serum creatinine ≤2.5 mg/dL, may be increased to 50 mg once daily if tolerated. Reduced to 25 mg every other day, if not tolerated.
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