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Endocrine: Gynecomastia, inability to achieve or maintain erection, irregular menses or amenorrhea, postmenopausal bleeding. Carcinoma of the breast has been reported in patients taking spironolactone, but a cause and effect relationship has not been established.
GI: diarrhea and cramping, gastric bleeding, gastritis, nausea, ulceration, vomiting.
Hepatic: A very few cases of mixed cholestatic/hepatocellular toxicity, with 1 reported fatality, have been reported with spironolactone administration.
Hypersensitivity: anaphylactic reactions, fever, maculopapular or erythematous cutaneous eruptions, urticaria, vasculitis.
Miscellaneous: agranulocytosis, hyperkalemia, renal dysfunction (including renal failure).
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