Hyles Indications/Uses

Edema: Spironolactone is used in the management of edema associated with excessive aldosterone excretion such as idiopathic edema and edema accompanying cirrhosis of the liver, nephrotic syndrome, and congestive heart failure, usually in conjunction with other diuretics.
Congestive heart failure: For the management of edema and sodium retention when patient is only partially responsive to, or is intolerant of, other therapeutic measures. Spironolactone is also indicated for patients with congestive heart failure taking digitalis when other therapies are considered inappropriate.
Cirrhosis of the liver accompanied by edema and/or ascites: For maintenance therapy together with bed rest and the restriction of fluid and sodium. Aldosterone levels may be exceptionally high in this condition.
Nephrotic syndrome: For nephrotic patients when treatment of the underlying disease, restriction of fluid and sodium intake, and the use of other diuretics do not provide on adequate response.
Essential hypertension: Usually in combination with other drugs, spironolactone is indicated for patients who cannot be treated adequately with other agents or for whom other agents are considered inappropriate.
Spironolactone may be useful to decrease the potassium loss caused by other diuretics and potentiate the hypotensive effects of those agents or other more potent hypotensive agents.
Congestive heart failure: Low-dose (e.g., 25-50 mg daily) spironolactone therapy has been used in conjunction with angiotensin-converting enzyme (ACE) inhibitors, loop diuretics, and occasionally cardiac glycosides in patients with severe congestive heart failure (CHF) whose condition was inadequately controlled by therapy with an ACE inhibitor and a loop diuretic.
Primary aldosteronism: Spironolactone is used in the diagnosis of primary aldosteronism and used for the short-term preoperative treatment of primary aldosteronism and for long-term maintenance therapy in patients with discrete aldosterone-producing adrenal adenomas who cannot undergo adrenalectomy or who decline surgery. The drug is also used for long-term maintenance therapy for patients with bilateral micronodular or macronodular adrenal hyperplasia (idiopathic hyperaldosteronism).
Hypokalemia: For the treatment of patients with hypokalemia when other measures are considered inappropriate or inadequate. Spironolactone is also indicated for the prophylaxis of hypokalemia in patients taking digitalis when other measures are considered inadequate or inappropriate.
Severe heart failure (New York Heart Association [NYHA] class III to IV): To increase survival and to reduce the need for hospitalization for heart failure when used in addition to standard therapy.