Sedation of initially intubated & mechanically ventilated patients during treatment in intensive care setting; non-intubated patients prior to &/or during surgical & other procedures.
IV infusion Individualized dosage.Adult ICU sedation Initiation: 1 mcg/kg loading infusion over 10 min. Maintenance: 0.2-0.7 mcg/kg/hr. Procedural sedation Initiation: 1 mcg/kg loading infusion over 10 min. 0.5 mcg/kg loading infusion over 10 min for less invasive procedures eg, ophth surgery. Maintenance: 0.6 mcg/kg/hr & titrated to desired clinical effect w/ dose ranging from 0.2-1 mcg/kg/hr. Awake fiberoptic intubation Initiation: 1 mcg/kg loading infusion over 10 min. Maintenance: 0.7 mcg/kg/hr until the endotracheal tube is secured. Patients >65 yrInitiation of procedural sedation 0.5 mcg/kg loading infusion over 10 min.
View Hydex overdosage for action to be taken in the event of an overdose.
Special Precautions
Decrease or stop infusion, increase rate of infusion, elevate lower extremities & use pressor agents if hypotension, bradycardia & sinus arrest occur. Not to be infused for >24 hr. Tolerance, tachyphylaxis & dose-related increase in adverse events w/ prolonged exposure beyond 24 hr. W/drawal events eg, nausea, vomiting & agitation after prolonged administration (several days); tachycardia &/or HTN. Arousability. Transient HTN during loading dose. Patients w/ advanced heart block &/or severe ventricular dysfunction; hypovolemia, DM or chronic HTN. Monitor patients continuously while receiving treatment. Concomitant administration w/ other vasodilators or -ve chronotropic agents. Hepatic impairment. Not recommended during pregnancy & in women of childbearing potential not using contraception. Lactation. Elderly.
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