Hypersensitivity including angioedema. Monitor patients w/ known allergy to thienopyridines. Increased risk of bleeding in patients ≥75 yr, w/ a propensity to bleed (eg, due to recent trauma, surgery or recurrent GI bleeding, or active PUD), w/ body wt <60 kg (10 mg maintenance dose is not recommended), concomitant use w/ medicines that may increase risk of bleeding including oral anticoagulants, clopidogrel, NSAIDs & fibrinolytics. Platelet transfusion for patients w/ active bleeding. Renal & moderate hepatic impairment (including ESRD). May prolong bleeding time. Discontinue treatment at least 7 days prior to surgery. Patients in whom the coronary anatomy has not been defined & urgent CABG is a possibility. Thrombotic thrombocytopenic purpura. Galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption. Concomitant use w/ morphine. Pregnancy & lactation. Childn <18 yr. Not recommended for patients ≥75 yr except in high-risk situations (patients w/ DM or history of MI).
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