Chronic hepatitis B 30-35 MIU/wk SC/IM as 5 MIU/day or 10 MIU 3 times/wk for 16-24 wk.
Childn 1-17 yr 3 MIU/m
2 3 times/wk (every other day) for the 1st wk of therapy. Increase to 6 MIU/m
2 3 times/wk SC. Max: 10 MIU 3 times/wk. Total therapy duration: 16-24 wk.
Chronic hepatitis C 3 MIU SC 3 times/wk for up to 18-24 mth.
Resp tract papillomatosis eg, laryngeal papillomatosis 3 MIU/m
2 SC 3 times/wk after surgical (laser) removal of tumor tissue.
Condylomata acuminatum 1 MIU injected into lesion 3 times/wk on alternate days for 3 wk. Max: ≤15 MIU/wk.
Malignant melanoma Adjuvant to surgery: 20 MIU/m
2 IV 5 times wkly for 4 wk, followed by 10 MIU/m
2 SC 3 times wkly for 48 wk. In combination w/ chemotherapy 15 MIU/m
2 IV 5 times wkly for 3 wk, followed by 10 MIU/m
2 SC 3 times wkly.
AIDS-Related Kaposi's sarcoma 30 MIU/m
2 SC/IM 3-5 times/wk or 50 MIU/m
2/day as 30 min IV infusion for 5 consecutive days followed by a min interval of 9 days until the next 5-day treatment period.
Concomitant administration w/ zidovudine (AZT) 5-10 MIU/m
2/day; AZT 100 mg every 4 hr.
Renal cell carcinoma Monotherapy: 3-30 MIU SC 3, 5 or 7 days/wk. Combination therapy: 3-20 MIU/m
2 SC.
Hairy cell leukemia 2 MIU/m
2 SC/IM 3 times/wk.
Non-Hodgkin's lymphoma 5 MIU SC 3 times/wk.
Cutaneous T-cell lymphoma 1-2 MIU/inj site 3 times/wk for 4 consecutive wk.
Multiple myeloma Induction therapy: 3-5 MIU/m
2 3 times/wk. Maintenance: SC 3-5 MIU/m
2 3 times/wk.
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