Bioferon Adverse Reactions

Site of Injection: In some cases pain and erythema was observed in the site of injection, symptoms that are well tolerated.
Systemic: The most frequent side effect is fever, which may be controlled with the use of paracetamol. This adverse effect is reversible and usually disappears during the first two weeks of treatment. Other frequent adverse effects that may occur are:a)Flu-like syndrome (headaches, hyperthermia, myalgia). This effect can also be controlled with paracetamol by administering 500 mg similar to the ones caused by a common flu (hyperthermia, shivering, headache, myalgia); b) Anorexia, asthenia, nausea or diarrhea may occur; c) Diminishment of number of circulating leukocytes and platelets. These parameters should be monitored with monthly laboratory count. It has been described in some cases and only with doses over 100 million daily units, side effects such as depression, confusion, somnolence, apathy and coma.
Extrapyramidal depression, cerebelous ataxia, cardiac arrhythmia, transaminase elevation and autoimmune diseases (autoimmune hemolytic anemia; thyroiditis, autoimmune thrombocytopenic purpura) have been seldom reported.