Medostatin Dosage/Direction for Use

Prior to treatment with lovastatin, the patient should be given a standard cholesterol-lowering diet and this should be continued during treatment with lovastatin.
Adult: Initially 20 mg once daily. Dosage can be adjusted if required but at intervals of not less than 4 weeks reaching a maximum of 80 mg daily given in single or divided doses with the morning and evening meals.
Patients Taking Immunosuppressive Drugs Concomitantly with Lovastatin: Maximum Recommended Dosage:  ≤20 mg daily.
If LDL-cholesterol levels fall <75 mg/100 mL or total plasma cholesterol levels fall <140 mg/100 mL, the dosage of lovastatin should be reduced.
Lovastatin is effective alone or in combination with bile-acid sequestrants.
Renal Insufficiency: Modification of dosage is not necessary in patients with moderate renal insufficiency but in patients with severe renal insufficiency (creatinine clearance <30 mL/min), dosages >20 mg/day should be carefully considered and if necessary, they should be implemented cautiously.