Hypersensitivity to lovastatin or to any other component of Medostatin.
Active liver disease or unexplained persistent elevations of serum transaminases.
Use in pregnancy: Medostatin is contraindicated during pregnancy.
Medostatin should be administered to women of childbearing age only when conceiving is highly unlikely for such patients. In case such a patient becomes pregnant while taking Medostatin, the therapy should be discontinued and the patient apprised of the potential hazard to the fetus.
Use in lactation: As with other drugs, Medostatin is excreted in the human milk and for this reason, women taking Medostatin should not breastfeed their infants.