Medostatin Adverse Reactions

Lovastatin is generally well tolerated; for the most part, adverse reactions have been mild and transient in nature.
Frequently: Flatulence, diarrhoea, constipation, nausea, dyspepsia, dizziness, blurred vision, headache, muscle cramps, myalgia, skin rashes and abdominal pain have been reported. Patient receiving active control agents had a similar or higher incidence of gastrointestinal effects.
Other Adverse Reactions Occurring Less Frequently: Fatigue, pruritus, dry mouth, insomnia, sleep disorders and dysgeusia. Myopathy and rhabdomyolysis have been reported rarely.
The following additional adverse reactions can occur: Hepatitis, cholestatic jaundice, vomiting, anorexia, paresthesia and psychic disturbances including anxiety; erythema multiforme, including Stevens-Johnson syndrome; toxic epidermal necrolysis.
An apparent hypersensitivity syndrome has been reported rarely which has included ≥1 of the following features: Anaphylaxis, angioedema, lupus-like syndrome, polymyalgia rheumatica, thrombocytopenia, leukopenia, hemolytic anemia, increased ESR, arthritis, arthralgia, urticaria, asthenia, photosensitivity, fever, flushing, chills, dyspnea and malaise.